Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors.

Li, Xiangqian; Xu, Qi; Li, Chao; Luo, Jiao; Li, Xiuxue; Wang, Lijun; Jiang, Bo; Shi, Dayong

Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors.

Li, Xiangqian; Xu, Qi; Li, Chao; Luo, Jiao; Li, Xiuxue; Wang, Lijun; Jiang, Bo; Shi, Dayong.

Afiliación

Li X; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.
Xu Q; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.
Li C; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.
Luo J; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.
Li X; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.
Wang L; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.
Jiang B; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.
Shi D; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China. Electronic address: shidayong@qdio.ac.cn.

Eur J Med Chem ; 166: 178-185, 2019 Mar 15.

Article en En | MEDLINE | ID: mdl-30711829

Asunto(s)

Diabetes Mellitus Tipo 2/complicaciones; Diabetes Mellitus Tipo 2/tratamiento farmacológico; Obesidad/complicaciones; Fenoles/química; Fenoles/farmacología; Proteína Tirosina Fosfatasa no Receptora Tipo 1/antagonistas & inhibidores; Animales; Peso Corporal/efectos de los fármacos; Línea Celular; Diabetes Mellitus Tipo 2/metabolismo; Diabetes Mellitus Tipo 2/patología; Evaluación Preclínica de Medicamentos; Inhibidores Enzimáticos/química; Inhibidores Enzimáticos/farmacocinética; Inhibidores Enzimáticos/farmacología; Inhibidores Enzimáticos/uso terapéutico; Insulina/metabolismo; Resistencia a la Insulina; Leptina/metabolismo; Ratones; Simulación del Acoplamiento Molecular; Fenoles/farmacocinética; Fenoles/uso terapéutico; Fosforilación/efectos de los fármacos; Conformación Proteica; Proteína Tirosina Fosfatasa no Receptora Tipo 1/química; Proteína Tirosina Fosfatasa no Receptora Tipo 1/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Seguridad; Transducción de Señal/efectos de los fármacos

Palabras clave

Anti-diabetic; BKS db mice; PTP1B inhibitor; Selectivity; Toxicity

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Diabetes Mellitus Tipo 2 / Proteína Tirosina Fosfatasa no Receptora Tipo 1 / Obesidad Límite: Animals Idioma: En Revista: Eur J Med Chem Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia

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