The effects of vitamin D supplementation on indices of glycemic control in Iranian diabetics: A systematic review and meta-analysis.
Complement Ther Clin Pract
; 34: 294-304, 2019 Feb.
Article
en En
| MEDLINE
| ID: mdl-30712741
ABSTRACT
BACKGROUND AND PURPOSE:
This systematic review and meta-analysis aimed to assess the effects of vitamin D supplements on indices of glycemic control [homeostatic model assessment-insulin resistance (HOMA-IR), hemoglobin A1C (HbA1C), fasting blood glucose (FBG), and quantitative insulin-sensitivity check index (QUICKI) and lipid profile in diabetic patients.METHODS:
Eight databases were searched, for randomized controlled trials (RCTs) or cross-sectional and cohort studies that have been published up to December 2017. We used the comprehensive meta-analysis (CMA) software for all statistical analysis and used the I2 index for assessing heterogeneity. A p value of <0.05 was considered as statistically significant.RESULTS:
We found 621 articles, and after the exclusion of ineligible publications, 82 studies remained to be assessed of which 37 were used for meta-analysis. Vitamin D supplementation was associated with a significant improvement in FBG (pâ¯=â¯0.001 and 95% CI -0.526 to -0.136) and HbA1C (pâ¯=â¯0.003 and 95% CI 1.719 to -0.361) in individuals with type 2 diabetes mellitus (T2DM); while in women with gestational diabetes mellitus (GDM) the reduction in FBG (pâ¯=â¯0.071 and 95% CI -0.873 to -0.035) and HbA1C (pâ¯=â¯0.199 and 95% CI 3.270 to 0.681) failed to reach statistical significance. Treatment with vitamin D supplements was associated with an improvement in HOMA-IR in pregnant diabetic women (pâ¯=â¯0.028 and 95% CI 0.924 to -0.053) and for individuals with diabetes mellitus (pâ¯=â¯0.005 and 95% CI 1.772 to -0.319). The pooled result of the cross-sectional meta-analysis indicated that serum vitamin D concentrations were significantly lower in diabetic patients than in healthy controls (pâ¯=â¯0.018 and 95% CI 0.587 to -0.054).CONCLUSION:
This meta-analysis suggests that vitamin D supplementation improves indices of glycemic control (FBG, HOMA-IR, and HbA1C) in patients with diabetes mellitus. Hence, vitamin D supplements may be of potential therapeutic value in diabetic patients, as an adjuvant therapy along with other treatments.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vitamina D
/
Glucemia
/
Diabetes Mellitus Tipo 2
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Complement Ther Clin Pract
Asunto de la revista:
ENFERMAGEM
/
OBSTETRICIA
/
PERINATOLOGIA
/
TERAPIAS COMPLEMENTARES
Año:
2019
Tipo del documento:
Article
País de afiliación:
Irán