Synthesis and Biological Evaluation of 3,9-Dioxatetraasteranes as C<sub>2</sub>-Symmetric HIV-1 Protease Inhibitors and Docking Study.

Li, Peng; Wang, Shijie; Wang, Huiqin; Yan, Hong

Synthesis and Biological Evaluation of 3,9-Dioxatetraasteranes as C₂-Symmetric HIV-1 Protease Inhibitors and Docking Study.

Li, Peng; Wang, Shijie; Wang, Huiqin; Yan, Hong.

Afiliación

Li P; Beijing Key Laboratory of Environmental and Viral Oncology, College of Life Science and Bioengineering, Beijing University of Technology.
Wang S; Beijing Key Laboratory of Environmental and Viral Oncology, College of Life Science and Bioengineering, Beijing University of Technology.
Wang H; Beijing Key Laboratory of Environmental and Viral Oncology, College of Life Science and Bioengineering, Beijing University of Technology.
Yan H; Beijing Key Laboratory of Environmental and Viral Oncology, College of Life Science and Bioengineering, Beijing University of Technology.

Biol Pharm Bull ; 42(2): 261-267, 2019.

Article en En | MEDLINE | ID: mdl-30713256

Asunto(s)

Inhibidores de la Proteasa del VIH/química; Inhibidores de la Proteasa del VIH/farmacología; Ureasa/química; Ureasa/farmacología; Azepinas/química; Azepinas/farmacología; Proteasa del VIH/metabolismo; Inhibidores de la Proteasa del VIH/síntesis química; VIH-1/efectos de los fármacos; VIH-1/enzimología; Humanos; Concentración 50 Inhibidora; Modelos Moleculares; Simulación del Acoplamiento Molecular; Relación Estructura-Actividad; Urea/análogos & derivados; Urea/química; Urea/farmacología; Ureasa/síntesis química

Palabras clave

3,9-dioxatetraasterane; docking study; human immunodeficiency virus (HIV)-1 protease inhibitor; pharmacological activity; synthesis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ureasa / Inhibidores de la Proteasa del VIH Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biol Pharm Bull Asunto de la revista: BIOQUIMICA / FARMACOLOGIA Año: 2019 Tipo del documento: Article

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