Synthesis of water soluble pentacyclic dihydroxyterpene carboxylic acid derivatives coupled amino acids and their inhibition activities on &#945;-glucosidase.

Zeng, Zhen; Yin, Xiaoli; Wang, Xueyuan; Yang, Wuying; Liu, Xiaoqin; Hong, Yanping

Synthesis of water soluble pentacyclic dihydroxyterpene carboxylic acid derivatives coupled amino acids and their inhibition activities on α-glucosidase.

Zeng, Zhen; Yin, Xiaoli; Wang, Xueyuan; Yang, Wuying; Liu, Xiaoqin; Hong, Yanping.

Afiliación

Zeng Z; Jiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering Jiangxi Agricultural University, Nanchang 33045, China.
Yin X; Library of Jiangxi Agricultural University, Nanchang 330045, China.
Wang X; Jiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering Jiangxi Agricultural University, Nanchang 33045, China.
Yang W; Jiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering Jiangxi Agricultural University, Nanchang 33045, China. Electronic address: yangwuyi2003@163.com.
Liu X; Jiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering Jiangxi Agricultural University, Nanchang 33045, China.
Hong Y; Jiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering Jiangxi Agricultural University, Nanchang 33045, China. Electronic address: xyqcjx@163.com.

Bioorg Chem ; 86: 277-287, 2019 05.

Article en En | MEDLINE | ID: mdl-30735848

Asunto(s)

Aminoácidos/farmacología; Inhibidores de Glicósido Hidrolasas/farmacología; Triterpenos/farmacología; alfa-Glucosidasas/metabolismo; Aminoácidos/química; Relación Dosis-Respuesta a Droga; Inhibidores de Glicósido Hidrolasas/síntesis química; Inhibidores de Glicósido Hidrolasas/química; Humanos; Conformación Molecular; Solubilidad; Relación Estructura-Actividad; Triterpenos/síntesis química; Triterpenos/química; Agua/química

Palabras clave

Corosolic acid; Maslinic acid; Water solubility; l-amino acids; α-Glucosidase inhibitory activities

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triterpenos / Alfa-Glucosidasas / Inhibidores de Glicósido Hidrolasas / Aminoácidos Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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