Systems Metabolic Engineering Strategies: Integrating Systems and Synthetic Biology with Metabolic Engineering.
Trends Biotechnol
; 37(8): 817-837, 2019 08.
Article
en En
| MEDLINE
| ID: mdl-30737009
Metabolic engineering allows development of microbial strains efficiently producing chemicals and materials, but it requires much time, effort, and cost to make the strains industrially competitive. Systems metabolic engineering, which integrates tools and strategies of systems biology, synthetic biology, and evolutionary engineering with traditional metabolic engineering, has recently been used to facilitate development of high-performance strains. The past decade has witnessed this interdisciplinary strategy continuously being improved toward the development of industrially competitive overproducer strains. In this article, current trends in systems metabolic engineering including tools and strategies are reviewed, focusing on recent developments in selection of host strains, metabolic pathway reconstruction, tolerance enhancement, and metabolic flux optimization. Also, future challenges and prospects are discussed.
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Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Biología Sintética
/
Ingeniería Metabólica
Idioma:
En
Revista:
Trends Biotechnol
Año:
2019
Tipo del documento:
Article
Pais de publicación:
Reino Unido