Nitro Sulfonyl Fluorides are a new pharmacophore for the development of antibiotics.
Mol Syst Des Eng
; 3(4): 599-603, 2018 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-30740245
ABSTRACT
The development of antibiotics against Gram-negative bacteria is a central problem in drug discovery. In this report, we demonstrate that aromatic sulfonyl fluorides with a nitro group in their ortho position have remarkable antibacterial activity and are active against drug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug resistant Acinetobacter baumannii, and Pseudomonas aeruginosa.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Mol Syst Des Eng
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos