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Nitro Sulfonyl Fluorides are a new pharmacophore for the development of antibiotics.
Sadlowski, Corinne; Park, Bora; Araújo, Clarissa; Das, Subhamoy; Kerr, D Lucas; He, Maomao; Han, Hesong; Riley, Lee; Murthy, Niren.
Afiliación
  • Sadlowski C; Department of Bioengineering, University of California, Berkeley, California, 94720, USA.
  • Park B; These authors contributed equally to this work.
  • Araújo C; Department of Bioengineering, University of California, Berkeley, California, 94720, USA.
  • Das S; These authors contributed equally to this work.
  • Kerr DL; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, 94720, USA.
  • He M; Department of Bioengineering, University of California, Berkeley, California, 94720, USA.
  • Han H; Department of Bioengineering, University of California, Berkeley, California, 94720, USA.
  • Riley L; Department of Bioengineering, University of California, Berkeley, California, 94720, USA.
  • Murthy N; Department of Bioengineering, University of California, Berkeley, California, 94720, USA.
Mol Syst Des Eng ; 3(4): 599-603, 2018 Aug 01.
Article en En | MEDLINE | ID: mdl-30740245
ABSTRACT
The development of antibiotics against Gram-negative bacteria is a central problem in drug discovery. In this report, we demonstrate that aromatic sulfonyl fluorides with a nitro group in their ortho position have remarkable antibacterial activity and are active against drug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug resistant Acinetobacter baumannii, and Pseudomonas aeruginosa.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mol Syst Des Eng Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mol Syst Des Eng Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos