Bone Metastasis: Find Your Niche and Fit in.
Trends Cancer
; 5(2): 95-110, 2019 02.
Article
en En
| MEDLINE
| ID: mdl-30755309
ABSTRACT
Metastasis to bones is determined by both intrinsic traits of metastatic tumor cells and properties appertaining to the bone microenvironment. Bone marrow niches are critical for all major steps of metastasis, including the seeding of disseminated tumor cells (DTCs) to bone, the survival of DTCs and microscopic metastases under dormancy, and the eventual outgrowth of overt metastases. In this review, we discuss the role of bone marrow niches in bone colonization. The emphasis is on complicated and dynamic nature of cancer cells-niche interaction, which may underpin the long-standing mystery of metastasis dormancy, and represent a therapeutic target for elimination of minimal residue diseases and prevention of life-taking, overt metastases.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Óseas
/
Nicho de Células Madre
Límite:
Humans
Idioma:
En
Revista:
Trends Cancer
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos