Antiproliferative ent-kaurane diterpenoids isolated from the roots of Zea mays L.
Fitoterapia
; 134: 44-49, 2019 Apr.
Article
en En
| MEDLINE
| ID: mdl-30763719
ABSTRACT
Four new ent-kaurane diterpenoid maizediterpenes A-D (1-4), along with fourteen known compounds were isolated from the roots of Zea mays (maize). Compounds 7, 15, 16 were isolated from this genus for the first time. The planar structures of the new compounds were determined by extensive analysis of their NMR and HR-ESI-MS spectra, and the absolute configurations were established on the basis of specific rotation in association with calculated ECD spectra. Compounds 2, 6 and 18 showed significant antiproliferative effects against five human cancer cell lines (A549, MDA-MB-231, SK-Hep-1, SNU638, HCT116) with IC50 values ranging from 1.99⯱â¯0.41⯵M to 15.18⯱â¯1.17⯵M.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Zea mays
/
Diterpenos de Tipo Kaurano
/
Antineoplásicos Fitogénicos
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Fitoterapia
Año:
2019
Tipo del documento:
Article
País de afiliación:
China