Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure.

Dohle, Wolfgang; Prota, Andrea E; Menchon, Grégory; Hamel, Ernest; Steinmetz, Michel O; Potter, Barry V L

Dohle, Wolfgang; Prota, Andrea E; Menchon, Grégory; Hamel, Ernest; Steinmetz, Michel O; Potter, Barry V L.

Afiliación

Dohle W; Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K.
Prota AE; Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, Villigen PSI CH-5232, Switzerland.
Menchon G; Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, Villigen PSI CH-5232, Switzerland.
Hamel E; Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick 21702, Maryland, United States.
Steinmetz MO; Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, Villigen PSI CH-5232, Switzerland.
Potter BVL; University of Basel, Biozentrum, Basel CH-4056, Switzerland.

ACS Omega ; 4(1): 755-764, 2019 Jan 31.

Article en En | MEDLINE | ID: mdl-30775645

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Omega Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos

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