Incretin Physiology and Pharmacology in the Intensive Care Unit.
Crit Care Clin
; 35(2): 341-355, 2019 Apr.
Article
en En
| MEDLINE
| ID: mdl-30784614
ABSTRACT
In health, postprandial glycemic excursions are attenuated via stimulation of insulin secretion, suppression of glucagon secretion, and slowing of gastric emptying. The incretin hormones, glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide, are primary modulators of this response. Drugs have recently been developed that exploit the incretin-axis for the management of type 2 diabetes. There is burgeoning interest in the potential of incretin therapies for the management of acute hyperglycemia in the critically ill. This article outlines basic incretin physiology, highlights relevant pharmacology, and briefly summarizes the literature on incretins for glycemic control in the critically ill.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glucemia
/
Cuidados Críticos
/
Índice Glucémico
/
Diabetes Mellitus Tipo 2
/
Incretinas
/
Hipoglucemiantes
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Crit Care Clin
Asunto de la revista:
TERAPIA INTENSIVA
Año:
2019
Tipo del documento:
Article