Genomic Imprinting and Physiological Processes in Mammals.
Cell
; 176(5): 952-965, 2019 02 21.
Article
en En
| MEDLINE
| ID: mdl-30794780
ABSTRACT
Complex multicellular organisms, such as mammals, express two complete sets of chromosomes per nucleus, combining the genetic material of both parents. However, epigenetic studies have demonstrated violations to this rule that are necessary for mammalian physiology; the most notable parental allele expression phenomenon is genomic imprinting. With the identification of endogenous imprinted genes, genomic imprinting became well-established as an epigenetic mechanism in which the expression pattern of a parental allele influences phenotypic expression. The expanding study of genomic imprinting is revealing a significant impact on brain functions and associated diseases. Here, we review key milestones in the field of imprinting and discuss mechanisms and systems in which imprinted genes exert a significant role.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Impresión Genómica
/
Mamíferos
Límite:
Animals
Idioma:
En
Revista:
Cell
Año:
2019
Tipo del documento:
Article