Extra-cellular matrix rigidity may dictate the fate of injury outcome.
J Theor Biol
; 469: 127-136, 2019 05 21.
Article
en En
| MEDLINE
| ID: mdl-30807758
ABSTRACT
After injury, while regeneration can be observed in hydra, planaria and some vertebrates, regeneration is rare in mammals and particularly in humans. In this paper, we investigate the mechanisms by which biological tissues recover after injury. We explore this question on adipose tissue, using the mathematical framework recently developed in Peurichard et al., J. Theoret. Biol. 429 (2017), pp. 61-81. Our assumption is that simple mechanical cues between the Extra-Cellular Matrix (ECM) and differentiated cells can explain adipose tissue morphogenesis and that regeneration requires after injury the same mechanisms. We validate this hypothesis by means of a two-dimensional Individual Based Model (IBM) of interacting adipocytes and ECM fiber elements. The model successfully generates regeneration or scar formation as functions of few key parameters, and seems to indicate that the fate of injury outcome could be mainly due to ECM rigidity.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tejido Adiposo
/
Matriz Extracelular
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Theor Biol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Francia