A Photocaged DNA Nanocapsule for Controlled Unlocking and Opening inside the Cell.
Bioconjug Chem
; 30(7): 1860-1863, 2019 07 17.
Article
en En
| MEDLINE
| ID: mdl-30811178
ABSTRACT
We report a nanosized DNA capsule with a photoinducible mechanical unlocking system for creation of a carrier for delivery system to the cells. A photocage system was introduced into the nanocapsule (NC) for control of opening of the NC with photoirradiation. The opening of the NC was observed by atomic force microscopy (AFM), and the dynamic opening of the NC was examined by fluorescence recovery from the quenching. The photocaged NC was introduced to the cell without toxicity and observed in the cytoplasm, and the photoinduced opening of the NC was observed in the cell. The selective unlocking and opening of the caged-NC in a single cell was successfully achieved by a laser irradiation to individual cells.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ADN
/
Preparaciones de Acción Retardada
/
Nanocápsulas
Límite:
Humans
Idioma:
En
Revista:
Bioconjug Chem
Asunto de la revista:
BIOQUIMICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Japón