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Structure of the IFNγ receptor complex guides design of biased agonists.
Mendoza, Juan L; Escalante, Nichole K; Jude, Kevin M; Sotolongo Bellon, Junel; Su, Leon; Horton, Tim M; Tsutsumi, Naotaka; Berardinelli, Steven J; Haltiwanger, Robert S; Piehler, Jacob; Engleman, Edgar G; Garcia, K Christopher.
Afiliación
  • Mendoza JL; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.
  • Escalante NK; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
  • Jude KM; Institute for Molecular Engineering and Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
  • Sotolongo Bellon J; Stanford Blood Center, Palo Alto, CA, USA.
  • Su L; Department of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA.
  • Horton TM; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.
  • Tsutsumi N; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
  • Berardinelli SJ; Division of Biophysics, Department of Biology, University of Osnabruck, Osnabruck, Germany.
  • Haltiwanger RS; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.
  • Piehler J; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
  • Engleman EG; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.
  • Garcia KC; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
Nature ; 567(7746): 56-60, 2019 03.
Article en En | MEDLINE | ID: mdl-30814731

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diseño de Fármacos / Interferón gamma / Receptores de Interferón Límite: Humans Idioma: En Revista: Nature Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diseño de Fármacos / Interferón gamma / Receptores de Interferón Límite: Humans Idioma: En Revista: Nature Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido