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Resveratrol Promotes Mitochondrial Biogenesis and Protects against Seizure-Induced Neuronal Cell Damage in the Hippocampus Following Status Epilepticus by Activation of the PGC-1α Signaling Pathway.
Chuang, Yao-Chung; Chen, Shang-Der; Hsu, Chung-Yao; Chen, Shu-Fang; Chen, Nai-Ching; Jou, Shuo-Bin.
Afiliación
  • Chuang YC; Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City 83301, Taiwan. ycchuang@cgmh.org.tw.
  • Chen SD; Institute for Translation Research in Biomedicine; Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City 83301, Taiwan. ycchuang@cgmh.org.tw.
  • Hsu CY; College of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan. ycchuang@cgmh.org.tw.
  • Chen SF; Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City 80708, Taiwan. ycchuang@cgmh.org.tw.
  • Chen NC; Department of Biological Science, National Sun Yat-sen University, Kaohsiung City 80424, Taiwan. ycchuang@cgmh.org.tw.
  • Jou SB; Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City 83301, Taiwan. chensd@adm.cgmh.org.tw.
Int J Mol Sci ; 20(4)2019 Feb 25.
Article en En | MEDLINE | ID: mdl-30823590
ABSTRACT
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is known to regulate mitochondrial biogenesis. Resveratrol is present in a variety of plants, including the skin of grapes, blueberries, raspberries, mulberries, and peanuts. It has been shown to offer protective effects against a number of cardiovascular and neurodegenerative diseases, stroke, and epilepsy. This study examined the neuroprotective effect of resveratrol on mitochondrial biogenesis in the hippocampus following experimental status epilepticus. Kainic acid was microinjected into left hippocampal CA3 in Sprague Dawley rats to induce bilateral prolonged seizure activity. PGC-1α expression and related mitochondrial biogenesis were investigated. Amounts of nuclear respiratory factor 1 (NRF1), mitochondrial transcription factor A (Tfam), cytochrome c oxidase 1 (COX1), and mitochondrial DNA (mtDNA) were measured to evaluate the extent of mitochondrial biogenesis. Increased PGC-1α and mitochondrial biogenesis machinery after prolonged seizure were found in CA3. Resveratrol increased expression of PGC-1α, NRF1, and Tfam, NRF1 binding activity, COX1 level, and mtDNA amount. In addition, resveratrol reduced activated caspase-3 activity and attenuated neuronal cell damage in the hippocampus following status epilepticus. These results suggest that resveratrol plays a pivotal role in the mitochondrial biogenesis machinery that may provide a protective mechanism counteracting seizure-induced neuronal damage by activation of the PGC-1α signaling pathway.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estado Epiléptico / Biogénesis de Organelos / Fármacos Neuroprotectores / Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma / Resveratrol / Hipocampo / Mitocondrias / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2019 Tipo del documento: Article País de afiliación: Taiwán

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estado Epiléptico / Biogénesis de Organelos / Fármacos Neuroprotectores / Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma / Resveratrol / Hipocampo / Mitocondrias / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2019 Tipo del documento: Article País de afiliación: Taiwán