Five new ent-kaurane diterpenes from Annona squamosa L. pericarps.
Nat Prod Res
; 34(15): 2243-2247, 2020 Aug.
Article
en En
| MEDLINE
| ID: mdl-30835539
ABSTRACT
In the present study, five new ent-kaurane diterpenes including 4α-hydroxy-17,19-dinor-ent-kaurane-16-one (1), 4ß-hydroxy-16ß-H-18-nor-ent-kaurane-17-oic acid (2), 4ß,17-dihydroxy-16α-acetoxy-18-nor-ent-kaurane (3), Annosquamosin Z (4) and 16α-H-ent-kaurane-17,18-dioic acid, 17-methy ester (5) were isolated from Annona squamosa L. pericarp. The compounds were also evaluated for their cytotoxic activities against SMMC-7721 and HepG2 cell lines, among which compound 3 exhibited potent cytotoxicity with IC50 value of less than 20 µM.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Annona
/
Diterpenos de Tipo Kaurano
Límite:
Humans
Idioma:
En
Revista:
Nat Prod Res
Año:
2020
Tipo del documento:
Article
País de afiliación:
China