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Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways.
Miner, Kent; Labitzke, Katja; Liu, Benxian; Wang, Paul; Henckels, Kathryn; Gaida, Kevin; Elliott, Robin; Chen, Jian Jeffrey; Liu, Longbin; Leith, Anh; Trueblood, Esther; Hensley, Kelly; Xia, Xing-Zhong; Homann, Oliver; Bennett, Brian; Fiorino, Mike; Whoriskey, John; Yu, Gang; Escobar, Sabine; Wong, Min; Born, Teresa L; Budelsky, Alison; Comeau, Mike; Smith, Dirk; Phillips, Jonathan; Johnston, James A; McGivern, Joseph G; Weikl, Kerstin; Powers, David; Kunzelmann, Karl; Mohn, Deanna; Hochheimer, Andreas; Sullivan, John K.
Afiliación
  • Miner K; Department of Inflammation Research, Amgen Inc., Thousand Oaks, CA, United States.
  • Labitzke K; Department of Therapeutic Discovery, Amgen Inc., Regensburg, Germany.
  • Liu B; Department of Inflammation Research, Amgen Inc., Thousand Oaks, CA, United States.
  • Wang P; Department of Therapeutic Discovery, Amgen Inc., Thousand Oaks, CA, United States.
  • Henckels K; Department of Inflammation Research, Amgen Inc., Thousand Oaks, CA, United States.
  • Gaida K; Department of Inflammation Research, Amgen Inc., Thousand Oaks, CA, United States.
  • Elliott R; Department of Inflammation Research, Amgen Inc., Thousand Oaks, CA, United States.
  • Chen JJ; Department of Medicinal Chemistry, Amgen Inc., Thousand Oaks, CA, United States.
  • Liu L; Department of Medicinal Chemistry, Amgen Inc., Thousand Oaks, CA, United States.
  • Leith A; Department of Inflammation Research, Amgen Inc., Seattle, WA, United States.
  • Trueblood E; Department of Comparative Biology and Safety Sciences, Amgen Inc., Seattle, WA, United States.
  • Hensley K; Department of Comparative Biology and Safety Sciences, Amgen Inc., Thousand Oaks, CA, United States.
  • Xia XZ; Department of Comparative Biology and Safety Sciences, Amgen Inc., South San Francisco, CA, United States.
  • Homann O; Department of Comparative Biology and Safety Sciences, Amgen Inc., Seattle, WA, United States.
  • Bennett B; Department of Comparative Biology and Safety Sciences, Amgen Inc., Thousand Oaks, CA, United States.
  • Fiorino M; Department of Comparative Biology and Safety Sciences, Amgen Inc., South San Francisco, CA, United States.
  • Whoriskey J; Department of Inflammation Research, Amgen Inc., Thousand Oaks, CA, United States.
  • Yu G; Genome Analysis Unit, Amgen Inc., South San Francisco, CA, United States.
  • Escobar S; Department of Inflammation Research, Amgen Inc., Thousand Oaks, CA, United States.
  • Wong M; Department of Inflammation Research, Amgen Inc., Thousand Oaks, CA, United States.
  • Born TL; Department of Inflammation Research, Amgen Inc., Thousand Oaks, CA, United States.
  • Budelsky A; Department of Inflammation Research, Amgen Inc., Thousand Oaks, CA, United States.
  • Comeau M; Department of Inflammation Research, Amgen Inc., Seattle, WA, United States.
  • Smith D; Department of Inflammation Research, Amgen Inc., Thousand Oaks, CA, United States.
  • Phillips J; Department of Inflammation Research, Amgen Inc., Seattle, WA, United States.
  • Johnston JA; Department of Inflammation Research, Amgen Inc., Seattle, WA, United States.
  • McGivern JG; Department of Inflammation Research, Amgen Inc., Seattle, WA, United States.
  • Weikl K; Department of Inflammation Research, Amgen Inc., Seattle, WA, United States.
  • Powers D; Department of Inflammation Research, Amgen Inc., Thousand Oaks, CA, United States.
  • Kunzelmann K; Department of Inflammation Research, Amgen Inc., Thousand Oaks, CA, United States.
  • Mohn D; Department of Therapeutic Discovery, Amgen Inc., Thousand Oaks, CA, United States.
  • Hochheimer A; Department of Therapeutic Discovery, Amgen Inc., Regensburg, Germany.
  • Sullivan JK; Department of Therapeutic Discovery, Amgen Inc., Thousand Oaks, CA, United States.
Front Pharmacol ; 10: 51, 2019.
Article en En | MEDLINE | ID: mdl-30837866
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Pharmacol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Pharmacol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza