Effects of acetylsalicylic acid on rats: An in vivo experimental study in azaserine-rat model.
J Cancer Res Ther
; 15(1): 231-236, 2019.
Article
en En
| MEDLINE
| ID: mdl-30880783
ABSTRACT
AIM:
The effect of acetylsalicylic acid (ASA) on thiol levels was studied in a rat model of azaserine carcinogenesis. MATERIALS ANDMETHODS:
ASA and azaserine were applied to the animals to research changes in cellular sulfhydryl (-SH) content and variations in free and protein-bound molecules containing the -SH group. Such effects in rats injected with azaserine were investigated at low (200 ppm) and high (400 ppm) concentrations of ASA over a relatively short (6 months) and a relatively long (12 months) period.RESULTS:
Changes in the hepatic, pancreatic, and renal -SH contents were also determined.CONCLUSION:
Compared to the other tissues studied, the liver contained the highest levels of both free and protein-bound -SH.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Azaserina
/
Carcinógenos
/
Antiinflamatorios no Esteroideos
/
Aspirina
/
Neoplasias
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
J Cancer Res Ther
Asunto de la revista:
NEOPLASIAS
/
TERAPEUTICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Turquía