Bioanalytical challenges and unique considerations to support pharmacokinetic characterization of bispecific biotherapeutics.

Ma, Mark; Colletti, Kelly; Yang, Tong-Yuan; Leung, Sheldon; Pederson, Susan; Hottenstein, Charles S; Xu, Xiaohui; Warrino, Dominic; Wakshull, Eric

Ma, Mark; Colletti, Kelly; Yang, Tong-Yuan; Leung, Sheldon; Pederson, Susan; Hottenstein, Charles S; Xu, Xiaohui; Warrino, Dominic; Wakshull, Eric.

Afiliación

Ma M; Alexion Pharmaceuticals, 100 College Street, New Haven, CT 06443, USA.
Colletti K; Charles River Laboratories, 6995 Longley Lane, Reno, NV 89511, USA.
Yang TY; Janssen BioTherapeutics, Janssen Research & Development, LLC,1400 McKean Road, Spring House, PA 19477, USA.
Leung S; Selecta Biosciences, Inc., 480 Arsenal Way, Watertown, MA 02472, USA.
Pederson S; Alder BioPharmaceuticals, Bothell, WA 98011, USA.
Hottenstein CS; GlaxoSmithKline Pharmaceuticals Research & Development, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
Xu X; Bristol-Myers Squibb, Route 206 & Provinceline Road, Princeton, NJ 08543, USA.
Warrino D; KCAS Biopharmaceutical & Biomarker Services , 12400 Shawnee Mission Parkway, Shawnee, KS 66216, USA.
Wakshull E; Genentech,1 DNA Way, South San Francisco, CA 94080, USA.

Bioanalysis ; 11(5): 427-435, 2019 Mar.

Article en En | MEDLINE | ID: mdl-30887822

Asunto(s)

Anticuerpos Biespecíficos/inmunología; Biotransformación/inmunología; Humanos

Palabras clave

bispecific molecule; functional assay; ligand binding assay; method development; method validation; multi-domain binding

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biotransformación / Anticuerpos Biespecíficos Límite: Humans Idioma: En Revista: Bioanalysis Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google