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Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients.
Liang, Chia-Pin; Dong, Jing; Ford, Tim; Reddy, Rohith; Hosseiny, Hamid; Farrokhi, Hamid; Beatty, Matthew; Singh, Kanwarpal; Osman, Hany; Vuong, Barry; Baldwin, Grace; Grant, Catriona; Giddings, Sarah; Gora, Michalina J; Rosenberg, Mireille; Nishioka, Norman; Tearney, Guillermo.
Afiliación
  • Liang CP; Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
  • Dong J; Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
  • Ford T; Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
  • Reddy R; Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
  • Hosseiny H; Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
  • Farrokhi H; Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
  • Beatty M; Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
  • Singh K; Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
  • Osman H; Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
  • Vuong B; Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
  • Baldwin G; Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
  • Grant C; Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
  • Giddings S; Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
  • Gora MJ; Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
  • Rosenberg M; ICube Laboratory, CNRS, Strasbourg University, Strasbourg, France.
  • Nishioka N; Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
  • Tearney G; Department of Gastroenterology, Harvard Medical School and Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Biomed Opt Express ; 10(3): 1207-1222, 2019 Mar 01.
Article en En | MEDLINE | ID: mdl-30891340
ABSTRACT
Tethered capsule endomicroscopy (TCE) is an emerging screening technology that comprehensively obtains microstructural OCT images of the gastrointestinal (GI) tract in unsedated patients. To advance clinical adoption of this imaging technique, it will be important to validate TCE images with co-localized histology, the current diagnostic gold standard. One method for co-localizing OCT images with histology is image-targeted laser marking, which has previously been implemented using a driveshaft-based, balloon OCT catheter, deployed during endoscopy. In this paper, we present a TCE device that scans and targets the imaging beam using a low-cost stepper motor that is integrated inside the capsule. In combination with a 4-laser-diode, high power 1430/1450 nm marking laser system (800 mW on the sample and 1s pulse duration), this technology generated clearly visible marks, with a spatial targeting accuracy of better than 0.5 mm. A laser safety study was done on swine esophagus ex vivo, showing that these exposure parameters did not alter the submucosa, with a large, 4-5x safety margin. The technology was demonstrated in living human subjects and shown to be effective for co-localizing OCT TCE images to biopsies obtained during subsequent endoscopy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomed Opt Express Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomed Opt Express Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA