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Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma.
Zimmerman, Matthew; McDonald, Stacey L; Ho-Liang, Hsin-Pin; Porubsky, Patrick; Nguyen, Quyen; Pharr, Cameron W; Perkowski, Andrew J; Smith, Robert; Schoenen, Frank J; Gold, Ben S; Zhang, David; Nathan, Carl F; Dartois, Véronique; Aubé, Jeffrey.
Afiliación
  • Zimmerman M; Public Health Research Institute, New Jersey Medical School, Rutgers, the State University of New Jersey, Newark, NJ, 07013, USA.
  • McDonald SL; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Ho-Liang HP; Public Health Research Institute, New Jersey Medical School, Rutgers, the State University of New Jersey, Newark, NJ, 07013, USA.
  • Porubsky P; Specialized Chemistry Center, University of Kansas, Lawrence, KS, 66045, USA.
  • Nguyen Q; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Pharr CW; Specialized Chemistry Center, University of Kansas, Lawrence, KS, 66045, USA.
  • Perkowski AJ; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Smith R; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Schoenen FJ; Specialized Chemistry Center, University of Kansas, Lawrence, KS, 66045, USA.
  • Gold BS; Specialized Chemistry Center, University of Kansas, Lawrence, KS, 66045, USA.
  • Zhang D; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, 10065, USA.
  • Nathan CF; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, 10065, USA.
  • Dartois V; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, 10065, USA.
  • Aubé J; Public Health Research Institute, New Jersey Medical School, Rutgers, the State University of New Jersey, Newark, NJ, 07013, USA. veronique.dartois@rutgers.edu.
J Antibiot (Tokyo) ; 72(6): 469-475, 2019 06.
Article en En | MEDLINE | ID: mdl-30903100
A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to ß-lactam cleavage in mouse plasma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cefalosporinas / Antibacterianos Límite: Animals Idioma: En Revista: J Antibiot (Tokyo) Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cefalosporinas / Antibacterianos Límite: Animals Idioma: En Revista: J Antibiot (Tokyo) Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido