The Role of NO Synthase in the Cardioprotective Effect of Substances of Humic Origin on the Model of Ischemia and Reperfusion of Isolated Rat Heart.
Bull Exp Biol Med
; 166(5): 598-601, 2019 Mar.
Article
en En
| MEDLINE
| ID: mdl-30903506
ABSTRACT
The cardioprotective and inotropic effects of standardized active natural substance based on high-molecular-weight compounds of humic origin were studied on the model of global ischemia (40 min) and reperfusion of isolated perfused rat heart. Preventive administration of the test substance (0.1 mg/ml) before ischemia/reperfusion modeling reduced reperfusion contracture and necrotic death of cardiomyocytes and promoted recovery of myocardial contractility. Blockade of NO synthase with L-NAME (100 µM) abolished the above effects of the test substance. It was hypothesized that NO synthase plays an important role in the development of the cardioprotective and inotropic effects of the test natural substance.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Daño por Reperfusión Miocárdica
/
Óxido Nítrico Sintasa
/
Isquemia
/
Miocardio
Límite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2019
Tipo del documento:
Article
País de afiliación:
Rusia