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The Role of NO Synthase in the Cardioprotective Effect of Substances of Humic Origin on the Model of Ischemia and Reperfusion of Isolated Rat Heart.
Lasukova, T V; Zykova, M V; Belousov, M V; Gorbunov, A S; Logvinova, L A; Dygai, A M.
Afiliación
  • Lasukova TV; Tomsk State Pedagogical University, Tomsk, Russia. tlasukova@mail.ru.
  • Zykova MV; Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. tlasukova@mail.ru.
  • Belousov MV; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
  • Gorbunov AS; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
  • Logvinova LA; Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Dygai AM; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
Bull Exp Biol Med ; 166(5): 598-601, 2019 Mar.
Article en En | MEDLINE | ID: mdl-30903506
ABSTRACT
The cardioprotective and inotropic effects of standardized active natural substance based on high-molecular-weight compounds of humic origin were studied on the model of global ischemia (40 min) and reperfusion of isolated perfused rat heart. Preventive administration of the test substance (0.1 mg/ml) before ischemia/reperfusion modeling reduced reperfusion contracture and necrotic death of cardiomyocytes and promoted recovery of myocardial contractility. Blockade of NO synthase with L-NAME (100 µM) abolished the above effects of the test substance. It was hypothesized that NO synthase plays an important role in the development of the cardioprotective and inotropic effects of the test natural substance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño por Reperfusión Miocárdica / Óxido Nítrico Sintasa / Isquemia / Miocardio Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2019 Tipo del documento: Article País de afiliación: Rusia
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño por Reperfusión Miocárdica / Óxido Nítrico Sintasa / Isquemia / Miocardio Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2019 Tipo del documento: Article País de afiliación: Rusia