The Effect of 20 Hz versus 1 Hz Repetitive Transcranial Magnetic Stimulation on Motor Dysfunction in Parkinson's Disease: Which Is More Beneficial?
J Parkinsons Dis
; 9(2): 379-387, 2019.
Article
en En
| MEDLINE
| ID: mdl-30909248
ABSTRACT
BACKGROUND:
There is evidence that both high and low frequency rTMS may have therapeutic effects on motor performance of Parkinson's disease.OBJECTIVE:
The aim of the study was to conduct the first direct comparison of the two approaches.METHODS:
52 PD patients were randomly classified into two groups. The first group received 20âHz and the 2nd group received 1âHz rTMS with a total of 2000 pulses over M1of each hemisphere for ten days. Effects were assessed with the Unified Parkinson's Disease Rating Scale part III (UPDRS), Instrumental Activity of Daily Living (IADL), and a self-assessment score (SA) before, after the last session, and one month later. Cortical excitability was measured before and after the end of sessions.RESULTS:
There was a significant improvement on all rating scales after either 1âHz or 20âHz rTMS, but the effect persisted for longer after 20âHz (treatment X time interaction for UPDRS and IADL (Pâ=â0.075 and 0.04, respectively). Neither treatment affected motor thresholds, but 20âHz rTMS increased MEP amplitude and the duration of transcallosal inhibition. In an exploratory analysis, each group was subdivided into akinetic-rigid and tremor dominant subgroups and the effects of 1âHz and 20âHz treatment recalculated. There was weak evidence that patients with an akinetic-rigid presentation may respond better than those with predominant tremor.CONCLUSION:
Both 20âHz and 1âHz rTMS improve motor function in PD, but 20âHz rTMS is more effective.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
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Estimulación Magnética Transcraneal
/
Corteza Motora
Tipo de estudio:
Clinical_trials
/
Prognostic_studies
Límite:
Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Parkinsons Dis
Año:
2019
Tipo del documento:
Article
País de afiliación:
Egipto