Bacterial TIR domain-derived peptides inhibit innate immune signaling and catabolic responses in chondrocyte.

Hong, Lei; Wang, Shijie; Guo, Jinpeng; Yin, Xin; Yu, Qianjin; Yang, Mingjuan; Wang, Yufei; Ke, Yuehua; Li, Wenfeng

Hong, Lei; Wang, Shijie; Guo, Jinpeng; Yin, Xin; Yu, Qianjin; Yang, Mingjuan; Wang, Yufei; Ke, Yuehua; Li, Wenfeng.

Afiliación

Hong L; Department of Orthopedics, Forth Medical Center, General Hospital of the Chinese People's Liberation Army, Beijing, 100048, People's Republic of China.
Wang S; College of Bioscience and Bioengineering, Hebei University of Science and Technology, Shijiazhuang, 050018, Hebei, People's Republic of China.
Guo J; Institute of Disease Control and Prevention, Beijing, 100071, People's Republic of China.
Yin X; Department of Orthopedics, Forth Medical Center, General Hospital of the Chinese People's Liberation Army, Beijing, 100048, People's Republic of China.
Yu Q; Department of Orthopedics, Forth Medical Center, General Hospital of the Chinese People's Liberation Army, Beijing, 100048, People's Republic of China.
Yang M; Institute of Disease Control and Prevention, Beijing, 100071, People's Republic of China.
Wang Y; Department of Laboratory Medicine, The Third Medical Center, General Hospital of the Chinese People's Liberation Army, Beijing, 100039, People's Republic of China. yufeiwang21@yahoo.com.
Ke Y; Institute of Disease Control and Prevention, Beijing, 100071, People's Republic of China. yuehuakebj@163.com.
Li W; Department of Orthopedics, Forth Medical Center, General Hospital of the Chinese People's Liberation Army, Beijing, 100048, People's Republic of China. tiantaindede@163.com.

Mol Biol Rep ; 46(2): 2493-2504, 2019 Apr.

Article en En | MEDLINE | ID: mdl-30919211

Asunto(s)

Proteínas de la Membrana Bacteriana Externa/farmacología; Condrocitos/inmunología; Inmunidad Innata/efectos de los fármacos; Animales; Bacterias/metabolismo; Proteínas de la Membrana Bacteriana Externa/metabolismo; Línea Celular; Células Cultivadas; Citocinas/metabolismo; Humanos; Inmunidad Innata/inmunología; Inflamación/metabolismo; Interleucina-1beta/metabolismo; Ratones; FN-kappa B/metabolismo; Osteoartritis/inmunología; Osteoartritis/fisiopatología; Péptidos/metabolismo; Dominios Proteicos; Receptores de Interleucina-1/metabolismo; Transducción de Señal/efectos de los fármacos; Factor de Necrosis Tumoral alfa/metabolismo

Palabras clave

Catabolic responses; Chondrocyte; Decoy peptide; Innate immune signaling; TLR pathway

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de la Membrana Bacteriana Externa / Condrocitos / Inmunidad Innata Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Mol Biol Rep Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos

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