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Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold.
Stepanek, Ondrej; Hin, Niyada; Thomas, Ajit G; Dash, Ranjeet P; Alt, Jesse; Rais, Rana; Rojas, Camilo; Slusher, Barbara S; Tsukamoto, Takashi.
Afiliación
  • Stepanek O; Johns Hopkins Drug Discovery, Johns Hopkins University, Baltimore, MD, 21205, USA.
  • Hin N; Johns Hopkins Drug Discovery, Johns Hopkins University, Baltimore, MD, 21205, USA.
  • Thomas AG; Johns Hopkins Drug Discovery, Johns Hopkins University, Baltimore, MD, 21205, USA.
  • Dash RP; Johns Hopkins Drug Discovery, Johns Hopkins University, Baltimore, MD, 21205, USA; Department of Neurology, Johns Hopkins University, Baltimore, MD, 21205, USA.
  • Alt J; Johns Hopkins Drug Discovery, Johns Hopkins University, Baltimore, MD, 21205, USA.
  • Rais R; Johns Hopkins Drug Discovery, Johns Hopkins University, Baltimore, MD, 21205, USA; Department of Neurology, Johns Hopkins University, Baltimore, MD, 21205, USA.
  • Rojas C; Johns Hopkins Drug Discovery, Johns Hopkins University, Baltimore, MD, 21205, USA; Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD, 21205, USA.
  • Slusher BS; Johns Hopkins Drug Discovery, Johns Hopkins University, Baltimore, MD, 21205, USA; Department of Neurology, Johns Hopkins University, Baltimore, MD, 21205, USA.
  • Tsukamoto T; Johns Hopkins Drug Discovery, Johns Hopkins University, Baltimore, MD, 21205, USA; Department of Neurology, Johns Hopkins University, Baltimore, MD, 21205, USA. Electronic address: ttsukamoto@jhmi.edu.
Eur J Med Chem ; 170: 276-289, 2019 May 15.
Article en En | MEDLINE | ID: mdl-30921693
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Esfingomielina Fosfodiesterasa / Inhibidores Enzimáticos / Imidazoles Límite: Animals / Humans / Male Idioma: En Revista: Eur J Med Chem Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Esfingomielina Fosfodiesterasa / Inhibidores Enzimáticos / Imidazoles Límite: Animals / Humans / Male Idioma: En Revista: Eur J Med Chem Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Francia