Harnessing poxviral know-how for anti-cytokine therapies.
J Biol Chem
; 294(13): 5228-5229, 2019 03 29.
Article
en En
| MEDLINE
| ID: mdl-30926761
ABSTRACT
Poxviruses have evolved efficient proteins that bind mammalian cytokines and chemokines to suppress host immunity. Here Pontejo et al. examine in detail how one such poxviral protein, CrmD, that has activity against both mammalian tumor necrosis factor and chemokines, interacts with its host targets. They apply their findings to refine a human anti-cytokine therapeutic and increase its specificity, providing an elegant example of the benefits of mining viral proteins for therapeutically useful information.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Poxviridae
/
Proteínas Virales
/
Citocinas
/
Antiinflamatorios
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Biol Chem
Año:
2019
Tipo del documento:
Article
País de afiliación:
Irlanda