Acute versus repeated administration of desipramine in rats and mice: relationships between brain concentrations and reduction of immobility in the swimming test.
Psychopharmacology (Berl)
; 90(1): 139-41, 1986.
Article
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| MEDLINE
| ID: mdl-3094053
ABSTRACT
Immobility scores in the swimming test and brain concentrations of desipramine were determined in rats and mice following repeated injection of the antidepressant versus acute administration of either a behaviorally effective or ineffective dose of the drug. Five injections (IP) of desipramine (each injection being performed at the measured T1/2 of the drug in the brain) reduced immobility scores by 30%, whereas this regimen resulted in brain drug concentrations not different from those obtained after a single, behaviorally ineffective dose of desipramine. It is suggested that the enhanced "antidepressant" response such as that frequently observed in animals after repeated injection of imipramine-like drugs does not involve accumulation of the drug in the brain.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Química Encefálica
/
Desipramina
/
Actividad Motora
/
Antidepresivos
Límite:
Animals
Idioma:
En
Revista:
Psychopharmacology (Berl)
Año:
1986
Tipo del documento:
Article