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Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans.
Che, Li; Chi, Wenna; Qiao, Yu; Zhang, Jie; Song, Xinhua; Liu, Ye; Li, Lei; Jia, Jiaoyuan; Pilo, Maria G; Wang, Jingxiao; Cigliano, Antonio; Ma, Zhilong; Kuang, Wenhua; Tang, Zefang; Zhang, Zemin; Shui, Guanghou; Ribback, Silvia; Dombrowski, Frank; Evert, Matthias; Pascale, Rosa Maria; Cossu, Carla; Pes, Giovanni Mario; Osborne, Timothy F; Calvisi, Diego F; Chen, Xin; Chen, Ligong.
Afiliación
  • Che L; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital, Beijing, China.
  • Chi W; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.
  • Qiao Y; School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, China.
  • Zhang J; Collaborative Innovation Center for Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China.
  • Song X; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.
  • Liu Y; Department of Oncology, National Center of Gerontology, Beijing Hospital, Beijing, China.
  • Li L; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital, Beijing, China.
  • Jia J; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.
  • Pilo MG; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.
  • Wang J; School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, China.
  • Cigliano A; School of Pharmacy, Huazhong University of Science and Technology Tongji Medical College, Wuhan, Hubei, China.
  • Ma Z; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.
  • Kuang W; Department of Oncology and Hematology, The Second Hospital, Jilin University, Changchun, Jilin, China.
  • Tang Z; Department of Medical, Surgical, and Experimental Sciences, University of Sassari, Sassari, Sardegna, Italy.
  • Zhang Z; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.
  • Shui G; Beijing University of Chinese Medicine, Beijing, China.
  • Ribback S; Institute of Pathology, University Medicine of Greifswald, Greifswald, Germany.
  • Dombrowski F; School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, China.
  • Evert M; School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, China.
  • Pascale RM; BIOPIC, Beijing Advanced Innovation Center for Genomics, and School of Life Sciences, Peking University, Beijing, China.
  • Cossu C; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
  • Pes GM; BIOPIC, Beijing Advanced Innovation Center for Genomics, and School of Life Sciences, Peking University, Beijing, China.
  • Osborne TF; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
  • Calvisi DF; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology Chinese Academy of Sciences, Beijing, China.
  • Chen X; Institute of Pathology, University Medicine of Greifswald, Greifswald, Germany.
  • Chen L; Institute of Pathology, University Medicine of Greifswald, Greifswald, Germany.
Gut ; 69(1): 177-186, 2020 01.
Article en En | MEDLINE | ID: mdl-30954949
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colesterol / Carcinoma Hepatocelular / Acido Graso Sintasa Tipo I / Ácidos Grasos / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Gut Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colesterol / Carcinoma Hepatocelular / Acido Graso Sintasa Tipo I / Ácidos Grasos / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Gut Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido