[Animal Models for Selective Nerve Transfers of the upper Extremity]. / Experimentelle Modelle für selektive Nerventransfers der oberen Extremität: Modellbeschreibung und neurophysiologische Effekte.
Handchir Mikrochir Plast Chir
; 51(4): 319-326, 2019 Aug.
Article
en De
| MEDLINE
| ID: mdl-30959533
ABSTRACT
INTRODUCTION:
Nerve transfers are an important tool to restore muscle function. Despite their popularity in reconstructive surgery, their effects on the motor unit remain largely unknown. Therefore, a realistic animal model is needed for the upper extremity, which is where the majority of nerve transfers are conducted. This work shows different upper extremity nerve transfer models in the rat, where elbow flexion was restored with different types of nerve transfer in adult and neonatal rats.METHODS:
Anatomy and microsurgical feasibility was first evaluated in 10 adult and 5 neonate Sprague Dawley rats. In 40 rats (30 adult and 10 neonate), a nerve transfer of the whole ulnar nerve or just the deep branch was performed to reinnervate the long head of the biceps muscle. After 12 weeks of regeneration, the transfer was evaluated for functional aspects such as muscle force and weight.RESULTS:
Neural anatomy was constant in all rats. All nerve transfers were successful and functional analyses showed a maximum tetanic muscle force of 2.47â +â 0.25 N after an ulnar nerve transfer. Deep branch transfers achieved 1.96â +â 0.65 N, and neonates achieved 1.1â +â 0.23 N. Control side was 2.78â +â 0.24 N. The muscle weight was 325.6â +â 0.24â mg for the control, 313.8â +â 0.25â mg after UN transfer, 226.7â +â 0.65â mg after deep branch transfer and 85.5â +â 0.23â mg for neonates.DISCUSSION:
For proper clinical translation, an upper extremity model is needed. Successful reinnervation in all groups was demonstrated, which indicates an excellent model for future research. Variations in functional parameters are likely the effect of different donor axon ratios. Neuronal plasticity also appears to play a major role in the regeneration potential.CONCLUSION:
This work illustrates several animal models to further investigate nerve transfers on all levels of the motor unit.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transferencia de Nervios
/
Neuropatías del Plexo Braquial
Límite:
Animals
Idioma:
De
Revista:
Handchir Mikrochir Plast Chir
Año:
2019
Tipo del documento:
Article