Your browser doesn't support javascript.
loading
Impact of serum omentin-1 levels on functional prognosis in nondiabetic patients with ischemic stroke.
Wu, Dong-Mei; Wang, Shan; Wen, Xin; Han, Xin-Rui; Wang, Yong-Jian; Shen, Min; Fan, Shao-Hua; Zhang, Zi-Feng; Shan, Qun; Li, Meng-Qiu; Hu, Bin; Lu, Jun; Chen, Gui-Quan; Zheng, Yuan-Lin.
Afiliación
  • Wu DM; Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University Xuzhou 221116, P. R. China.
  • Wang S; College of Health Sciences, Jiangsu Normal University Xuzhou 221116, P. R. China.
  • Wen X; Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University Xuzhou 221116, P. R. China.
  • Han XR; College of Health Sciences, Jiangsu Normal University Xuzhou 221116, P. R. China.
  • Wang YJ; Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University Xuzhou 221116, P. R. China.
  • Shen M; College of Health Sciences, Jiangsu Normal University Xuzhou 221116, P. R. China.
  • Fan SH; Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University Xuzhou 221116, P. R. China.
  • Zhang ZF; College of Health Sciences, Jiangsu Normal University Xuzhou 221116, P. R. China.
  • Shan Q; Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University Xuzhou 221116, P. R. China.
  • Li MQ; College of Health Sciences, Jiangsu Normal University Xuzhou 221116, P. R. China.
  • Hu B; Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University Xuzhou 221116, P. R. China.
  • Lu J; College of Health Sciences, Jiangsu Normal University Xuzhou 221116, P. R. China.
  • Chen GQ; Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University Xuzhou 221116, P. R. China.
  • Zheng YL; College of Health Sciences, Jiangsu Normal University Xuzhou 221116, P. R. China.
Am J Transl Res ; 11(3): 1854-1863, 2019.
Article en En | MEDLINE | ID: mdl-30972209
OBJECTIVE: Omentin-1, an adipokine released from visceral fat tissue, is associated with diabetes and stroke. The purpose of this study was to assess the impact of serum omentin-1 levels on functional prognosis in nondiabetic patients with ischemic stroke. METHODS: From March 2016 to December 2017, consecutive patients with first-ever ischemic stroke admitted to our hospital, China, were recorded. Functional impairment was evaluated at 3-month after admission using the modified Rankin scale (mRS). Uni-and multivariate analyses with Cox proportional hazard regression was used for assessing the relationship between serum level of omentin-1 and functional outcome. RESULTS: We recorded 209 stroke patients, 52 of them (24.9%) experienced as poor functional outcome. The obtained omentin-1 level in patients with poor outcome was lower than in those patients with good outcome [100.8 (80.9-131.6) ng/ml vs. 137.6 (IQR, 106.1-171.5) ng/ml; Z=4.692; P<0.001). Multivariate analysis models were used to assess stroke outcome according to omentin-1 quartiles (the highest quartile [Q4] as the reference), the 1st and 2nd quartile of omentin-1 were compared against the Q4, and the risks were increased by 505% (HR=6.05; 95% CI: 2.13-12.15; P=0.007) and 215% (31.5; 1.21-7.98; P=0.03), respectively. The inclusion of omentin-1 in the routine prediction model for the prediction of poor functional outcome, enhanced the NRI (P=0.006) and IDI (P=0.001) values, confirming the effective reclassification and discrimination. Kaplan-Meier analysis suggested that the patients with low serum omentin-1 levels had a higher risk of death than those patients with high levels of omentin-1 (log-rank test P=0.033). CONCLUSION: In this cohort of nondiabetic patients with ischemic stroke, a reduced baseline level of serum omentin-1 was related with an increased risk for poor functional outcome or death, independent of baseline variables.
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Am J Transl Res Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Am J Transl Res Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos