Monoamine Oxidase B Binding of 18F-THK5351 to Visualize Glioblastoma and Associated Gliosis: An Autopsy-Confirmed Case.
Clin Nucl Med
; 44(6): 507-509, 2019 Jun.
Article
en En
| MEDLINE
| ID: mdl-30985435
ABSTRACT
An 86-year-old woman with cognitive impairment and left hemiparesis underwent F-THK5351 PET 4 months before her death. In addition to "normal" off-target binding in the basal ganglia, abnormal accumulation was observed along the pyramidal tract and around the right basal ganglia as ring-shaped uptake that overlapped a gadolinium-enhanced lesion. Postmortem pathological examination revealed that she had glioblastoma multiforme with associated gliosis, in which monoamine oxidase B (MAO-B) activity is increased. In vitro autoradiography of the corresponding lesion demonstrated specific binding of F-THK5351, which was blocked by an MAO-B-selective ligand. Thus, F-THK5351 PET may reflect glioblastomas and associated gliosis by binding to MAO-B.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quinolinas
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Neoplasias Encefálicas
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Glioblastoma
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Radiofármacos
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Tomografía de Emisión de Positrones
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Aminopiridinas
Tipo de estudio:
Risk_factors_studies
Límite:
Aged80
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Female
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Humans
Idioma:
En
Revista:
Clin Nucl Med
Año:
2019
Tipo del documento:
Article