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Preparation of azidophenyl-low molecular chitosan derivative micro particles for enhance drug delivery.
Kim, Shin-Woong; Lee, Tae-Hoon; Lee, Young-Gi; Ito, Yoshihiro; Son, Tae-Il.
Afiliación
  • Kim SW; Department of Systems Biotechnology, Chung-Ang University, Anseong-si, Gyeonggi-do, Republic of Korea.
  • Lee TH; Department of Systems Biotechnology, Chung-Ang University, Anseong-si, Gyeonggi-do, Republic of Korea.
  • Lee YG; Department of Electronic Materials, Samsung SDI Company Ltd., Suwon 443-803, Republic of Korea.
  • Ito Y; Nano Medical Engineering Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
  • Son TI; Department of Systems Biotechnology, Chung-Ang University, Anseong-si, Gyeonggi-do, Republic of Korea. Electronic address: tisohn@cau.ac.kr.
Int J Biol Macromol ; 133: 875-880, 2019 Jul 15.
Article en En | MEDLINE | ID: mdl-31029627
ABSTRACT
Systems for delivering damaged tissue by immobilization of a bioactive substance or a protein drug for rapid recovery of a patient are being studied. To immobilize drugs using natural polymer, photo-immobilization method has been designed. Immobilization through photo-reaction is a new technology that stabilizes drugs or growth factors for sustained release. Introduction of photo-reactive functional groups into biocompatible natural polymers produces materials applicable to the medical field. Since chitosan is a natural polymer with stability and biocompatibility, this study attempts to use chitosan as a mediator of drug delivery. In addition, If the form of the immobilized biomaterial is made into a micro-sized particle, it can be utilized as an injectable material in addition to the stability of the photo-immobilization. In photo-immobilization in particle form, the probability of exposure to the enzyme in the body is lower than if it is injected into the body in the conventional free state. In addition, since it can be freely injected into a desired target site, it can be used for various medical applications. Therefore, it is expected that various effects of growth factors and drugs can be utilized and additional effects can be obtained by photo-immobilization together with various effects.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Azidas / Portadores de Fármacos / Quitosano / Microesferas Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2019 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Azidas / Portadores de Fármacos / Quitosano / Microesferas Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2019 Tipo del documento: Article
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