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A novel low molecular weight nanocomposite hydrogel formulation for intra-tumoural delivery of anti-cancer drugs.
Staka, Ivana; Cadete, Ana; Surikutchi, Bhanu Teja; Abuzaid, Haneen; Bradshaw, Tracey D; Alonso, Maria J; Marlow, Maria.
Afiliación
  • Staka I; CIMUS Research University, University of Santiago de Compostela, 15706 Campus Vida, Spain; Centre for Biomolecular Sciences, University of Nottingham, NG7 2RD, UK; Boots Science Building, School of Pharmacy, University of Nottingham, NG7 2RD, UK.
  • Cadete A; CIMUS Research University, University of Santiago de Compostela, 15706 Campus Vida, Spain.
  • Surikutchi BT; Boots Science Building, School of Pharmacy, University of Nottingham, NG7 2RD, UK.
  • Abuzaid H; Centre for Biomolecular Sciences, University of Nottingham, NG7 2RD, UK.
  • Bradshaw TD; Centre for Biomolecular Sciences, University of Nottingham, NG7 2RD, UK.
  • Alonso MJ; CIMUS Research University, University of Santiago de Compostela, 15706 Campus Vida, Spain. Electronic address: mariaj.alonso@usc.es.
  • Marlow M; Boots Science Building, School of Pharmacy, University of Nottingham, NG7 2RD, UK. Electronic address: maria.marlow@nottingham.ac.uk.
Int J Pharm ; 565: 151-161, 2019 Jun 30.
Article en En | MEDLINE | ID: mdl-31029659
ABSTRACT
Herein, an injectable formulation composed of a low molecular weight gelator (LMWG) based hydrogel and drug-loaded polymeric nanocapsules (NCs) is described. The NCs, made of hyaluronic acid and polyglutamic acid and loaded with C14-Gemcitabine (GEM C14), showed a size of 40 and 80 nm and a encapsulation efficiency >90%. These NCs exhibited a capacity to control the release of the encapsulated drug for >1 month. GEM C14-loaded NCs showed activity against various cancer cell lines in vitro; cell growth inhibition by 50% (GI50) values of 15 ±â€¯6, 10 ±â€¯9, 13 ±â€¯3 and 410 ±â€¯463 nM were obtained in HCT 116, MIA PaCa-2, Panc-1 and Panc-1 GEM resistant cell lines respectively. Nanocomposite hydrogels were prepared using the LMWG - N4-octanoyl-2'-deoxycytidine and loaded for the first time with polymeric NCs. 2% and 4% w/v nanocapsule concentrations as compared to 8% w/v NC concentrations with 2% and 3% w/v gelator concentrations gave mechanically stronger gels as determined by oscillatory rheology. Most importantly, the nanocomposite formulation reformed instantly into a gel after injection through a needle. Based on these properties, the nanocomposite gel formulation has potential for the intratumoural delivery of anticancer drugs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Desoxicitidina / Nanocompuestos / Antineoplásicos Límite: Humans Idioma: En Revista: Int J Pharm Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Desoxicitidina / Nanocompuestos / Antineoplásicos Límite: Humans Idioma: En Revista: Int J Pharm Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido