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Antimicrobial Activity of Compounds Containing Silver Nanoparticles and Calcium Glycerophosphate in Combination with Tyrosol.
Souza, José Antonio Santos; Barbosa, Debora Barros; do Amaral, Jackeline Gallo; Monteiro, Douglas Roberto; Gorup, Luiz Fernando; de Souza Neto, Francisco Nunes; Fernandes, Renan Aparecido; Fernandes, Gabriela Lopes; de Camargo, Emerson Rodrigues; Agostinho, Alessandra Marçal; Delbem, Alberto Carlos Botazzo.
Afiliación
  • Souza JAS; 1Department of Pediatric Dentistry and Public Health, School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba, SP 16015-050 Brazil.
  • Barbosa DB; 1Department of Pediatric Dentistry and Public Health, School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba, SP 16015-050 Brazil.
  • do Amaral JG; 1Department of Pediatric Dentistry and Public Health, School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba, SP 16015-050 Brazil.
  • Monteiro DR; 2Graduate Program in Dentistry (GPD - Master's Degree), University of Western São Paulo (UNOESTE), Presidente Prudente, São Paulo Brazil.
  • Gorup LF; 3Federal University of Grande Dourados, Dourados, Mato Grosso do Sul Brazil.
  • de Souza Neto FN; 4Federal University of São Carlos, São Carlos, São Paulo Brazil.
  • Fernandes RA; University Center of Adamantina (UNIFAI), Adamantina, São Paulo Brazil.
  • Fernandes GL; 1Department of Pediatric Dentistry and Public Health, School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba, SP 16015-050 Brazil.
  • de Camargo ER; 4Federal University of São Carlos, São Carlos, São Paulo Brazil.
  • Agostinho AM; 6Michigan State University, East Lansing, MI USA.
  • Delbem ACB; 1Department of Pediatric Dentistry and Public Health, School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba, SP 16015-050 Brazil.
Indian J Microbiol ; 59(2): 147-153, 2019 Jun.
Article en En | MEDLINE | ID: mdl-31031428
Nanocomposites containing antimicrobial agents and calcium phosphates have been developed. Thus, this study assessed the effects of two compounds containing silver nanoparticles (AgNPs) and ß-calcium glycerophosphate (CaGP), associated or not with tyrosol (TYR), against planktonic cells and biofilms of Candida albicans and Streptococcus mutans. The nanocompounds were synthesized through chemical and 'green' processes and characterized by scanning electron microscopy. The minimum and fractional inhibitory concentrations of each compound were determined for planktonic cells. Next, 24-h single biofilms of C. albicans and S. mutans were treated for 24 h with the nanocompounds alone or in combination with TYR, and the antibiofilm effect was assessed through enumeration of colony forming units. Biofilm data were statistically examined using one-way ANOVA and the Kruskal-Wallis test (α = 0.05). The chemically synthesized nanocompound in combination with TYR demonstrated a synergistic effect against planktonic cells of C. albicans and S. mutans. For the nanocompound obtained through the 'green' route associated with TYR, a synergistic effect was observed only against C. albicans. For biofilms, only the combination obtained through the 'green' route + TYR demonstrated a synergistic effect against C. albicans. Our results may contribute to the development of oral care products containing AgNPs-CaGP and TYR to combat oral infections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Indian J Microbiol Año: 2019 Tipo del documento: Article Pais de publicación: India

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Indian J Microbiol Año: 2019 Tipo del documento: Article Pais de publicación: India