Relationship between mitofusin 2 and cancer.
Adv Protein Chem Struct Biol
; 116: 209-236, 2019.
Article
en En
| MEDLINE
| ID: mdl-31036292
ABSTRACT
Mitochondria are dynamic organelles whose actions are fundamental for cell viability. Within the cell, the mitochondrial system is incessantly modified via the balance between fusion and fission processes. Among other proteins, mitofusin 2 is a central protagonist in all these mitochondrial events (fusion, trafficking, contacts with other organelles), the balance of which causes the correct mitochondrial action, shape, and distribution within the cell. Here we examine the structural and functional characteristics of mitofusin 2, underlining its essential role in numerous intracellular pathways, as well as in the pathogenesis of cancer.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Mitocondriales
/
GTP Fosfohidrolasas
/
Mitocondrias
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Adv Protein Chem Struct Biol
Asunto de la revista:
BIOLOGIA
/
BIOQUIMICA
Año:
2019
Tipo del documento:
Article