Eisosomes at the intersection of TORC1 and TORC2 regulation.
Traffic
; 20(8): 543-551, 2019 08.
Article
en En
| MEDLINE
| ID: mdl-31038844
ABSTRACT
Eisosomes are furrows in the yeast plasma membrane that form a membrane domain with distinct lipid and protein composition. Recent studies highlighted the importance of this domain for the regulation of proton-nutrient symporters. The amino acids and other nutrients, which these transporters deliver to the cytoplasm not only feed into metabolic pathways but also activate the metabolic regulator TORC1. Eisosomes have also been shown to harbor the membrane stress sensors Slm1 and Slm2. Membrane tension caused by hypoosmotic shock results in the redistribution of Slm1/2 from eisosomes to TORC2 which in turn regulates lipid synthesis. Therefore, eisosomes function upstream of both TORC1 and TORC2 regulation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Membrana Celular
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Sistemas de Transporte de Aminoácidos
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Proteínas de Saccharomyces cerevisiae
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Diana Mecanicista del Complejo 1 de la Rapamicina
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Diana Mecanicista del Complejo 2 de la Rapamicina
Idioma:
En
Revista:
Traffic
Asunto de la revista:
FISIOLOGIA
Año:
2019
Tipo del documento:
Article