Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection.
AIDS
; 33(7): 1253-1256, 2019 06 01.
Article
en En
| MEDLINE
| ID: mdl-31045943
ABSTRACT
Soluble forms of the coinhibitory receptors programmed death 1 (PD-1) and Tim-3 exist, but their relationship with T-cell surface expression remains unclear. When measured by an enzyme-linked immunosorbent assay in plasma, soluble PD-1, and soluble Tim-3 were elevated during primary HIV infection, decreased on antiretroviral therapy to levels found in controls, and correlated with cell surface expression. We conclude that soluble PD-1 and soluble Tim-3 are easy to measure biomarkers of immune exhaustion which potentially eliminate the need for flow cytometry.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plasma
/
Infecciones por VIH
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Linfocitos T CD8-positivos
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Receptor de Muerte Celular Programada 1
/
Receptor 2 Celular del Virus de la Hepatitis A
Límite:
Adult
/
Aged
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
AIDS
Asunto de la revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Año:
2019
Tipo del documento:
Article