A Review of Chronic Leukoencephalopathy among Survivors of Childhood Cancer.
Pediatr Neurol
; 101: 2-10, 2019 12.
Article
en En
| MEDLINE
| ID: mdl-31047756
ABSTRACT
Currently, there are an estimated 400,000 long-term survivors of childhood cancer in the United States. Chronic leukoencephalopathy is a potential devastating late effect that can manifest as a range of neurological and neurocognitive sequelae. Survivors of the acute lymphocytic leukemia, central nervous system tumors, and stem cell transplant have frequently been exposed to cranial radiation, systemic and intrathecal chemotherapy, which places them at risk of developing chronic leukoencephalopathy. Defining leukoencephalopathy and its neuroimaging characteristics, the population of survivors at risk, its long-term consequences, and identifying prevention and intervention strategies can potentially mitigate the morbidity of these survivors. Better understanding of those at risk of leukoencephalopathy and its symptoms can lead to an improved quality of life for these cancer survivors.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Calidad de Vida
/
Encéfalo
/
Leucoencefalopatías
/
Supervivientes de Cáncer
Tipo de estudio:
Prognostic_studies
Aspecto:
Patient_preference
Límite:
Child
/
Humans
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Pediatr Neurol
Asunto de la revista:
NEUROLOGIA
/
PEDIATRIA
Año:
2019
Tipo del documento:
Article