Pharmacokinetic characterization of kalata B1 and related therapeutics built on the cyclotide scaffold.

Poth, Aaron G; Huang, Yen-Hua; Le, Thao T; Kan, Meng-Wei; Craik, David J

Poth, Aaron G; Huang, Yen-Hua; Le, Thao T; Kan, Meng-Wei; Craik, David J.

Afiliación

Poth AG; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia. Electronic address: a.poth@imb.uq.edu.au.
Huang YH; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia. Electronic address: y.huang@imb.uq.edu.au.
Le TT; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia. Electronic address: thaothithu.le@ecu.edu.au.
Kan MW; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia. Electronic address: a.kan@imb.uq.edu.au.
Craik DJ; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia. Electronic address: d.craik@imb.uq.edu.au.

Int J Pharm ; 565: 437-446, 2019 Jun 30.

Article en En | MEDLINE | ID: mdl-31063836

Asunto(s)

Ciclotidas/farmacocinética; Administración Oral; Animales; Disponibilidad Biológica; Proteínas Sanguíneas/metabolismo; Ciclotidas/sangre; Humanos; Masculino; Modelos Biológicos; Unión Proteica; Ratas; Ratas Wistar

Palabras clave

Cyclotide; Drug scaffold; Grafting; Kalata B1 (PubChem CID: 52945815); Knottin; Oral bioavailability; Pharmacokinetics

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ciclotidas Límite: Animals / Humans / Male Idioma: En Revista: Int J Pharm Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos

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