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Commonly integrated epigenetic modifications of differentially expressed genes lead to adaptive resistance in cancer.
Emran, Abdullah Al; Marzese, Diego M; Menon, Dinoop R; Hammerlindl, Heinz; Ahmed, Farzana; Richtig, Erika; Duijf, Pascal; Hoon, Dave Sb; Schaider, Helmut.
Afiliación
  • Emran AA; Dermatology Research Centre, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
  • Marzese DM; Centenary Institute of Cancer Medicine & Cell Biology, University of Sydney, Camperdown, NSW, Australia.
  • Menon DR; Department of Translational Molecular Medicine, John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA.
  • Hammerlindl H; Department of Translational Molecular Medicine, John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA.
  • Ahmed F; Dermatology Research Centre, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
  • Richtig E; The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
  • Duijf P; Department of Dermatology, Medical University of Graz, Graz, Austria.
  • Hoon DS; The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
  • Schaider H; Centenary Institute of Cancer Medicine & Cell Biology, University of Sydney, Camperdown, NSW, Australia.
Epigenomics ; 11(7): 732-737, 2019 05.
Article en En | MEDLINE | ID: mdl-31070054
ABSTRACT

Aim:

To investigate the integrated epigenetic regulation of acquired drug resistance in cancer. Materials &

methods:

Our gene expression data of five induced drug-tolerant cell models, one resistant cell line and one publicly available drug-resistant dataset were integrated to identify common differentially expressed genes and pathways. ChIP-seq and DNA methylation by HM450K beadchip were used to study the epigenetic profile of differential expressed genes. Results &

conclusion:

Integrated transcriptomic analysis identified a common 'viral mimicry' related gene signature in induced drug-tolerant cells and the resistant state. Analysis of the epigenetic regulation revealed a common set of down-regulated genes, which are marked and regulated by a concomitant loss of H3K4me3, gain of H3K9me3 and increment of regional DNA methylation levels associated with tumor suppressor genes and apoptotic signaling.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Epigenomics Año: 2019 Tipo del documento: Article País de afiliación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Epigenomics Año: 2019 Tipo del documento: Article País de afiliación: Australia