Commonly integrated epigenetic modifications of differentially expressed genes lead to adaptive resistance in cancer.
Epigenomics
; 11(7): 732-737, 2019 05.
Article
en En
| MEDLINE
| ID: mdl-31070054
ABSTRACT
Aim:
To investigate the integrated epigenetic regulation of acquired drug resistance in cancer. Materials &methods:
Our gene expression data of five induced drug-tolerant cell models, one resistant cell line and one publicly available drug-resistant dataset were integrated to identify common differentially expressed genes and pathways. ChIP-seq and DNA methylation by HM450K beadchip were used to study the epigenetic profile of differential expressed genes. Results &conclusion:
Integrated transcriptomic analysis identified a common 'viral mimicry' related gene signature in induced drug-tolerant cells and the resistant state. Analysis of the epigenetic regulation revealed a common set of down-regulated genes, which are marked and regulated by a concomitant loss of H3K4me3, gain of H3K9me3 and increment of regional DNA methylation levels associated with tumor suppressor genes and apoptotic signaling.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Epigenomics
Año:
2019
Tipo del documento:
Article
País de afiliación:
Australia