New Insights Into the Kinetics and Variability of Egg Excretion in Controlled Human Hookworm Infections.
J Infect Dis
; 220(6): 1044-1048, 2019 08 09.
Article
en En
| MEDLINE
| ID: mdl-31077279
ABSTRACT
Four healthy volunteers were infected with 50 Necator americanus infective larvae (L3) in a controlled human hookworm infection trial and followed for 52 weeks. The kinetics of fecal egg counts in volunteers was assessed with Bayesian multilevel analysis, which revealed an increase between weeks 7 and 13, followed by an egg density plateau of about 1000 eggs/g of feces. Variation in egg counts was minimal between same-day measurements but varied considerably between days, particularly during the plateau phase. These analyses pave the way for the controlled human hookworm model to accelerate drug and vaccine efficacy studies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Necator americanus
/
Larva
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Modelos Biológicos
/
Necatoriasis
Tipo de estudio:
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
J Infect Dis
Año:
2019
Tipo del documento:
Article