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Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
Law, Philip J; Timofeeva, Maria; Fernandez-Rozadilla, Ceres; Broderick, Peter; Studd, James; Fernandez-Tajes, Juan; Farrington, Susan; Svinti, Victoria; Palles, Claire; Orlando, Giulia; Sud, Amit; Holroyd, Amy; Penegar, Steven; Theodoratou, Evropi; Vaughan-Shaw, Peter; Campbell, Harry; Zgaga, Lina; Hayward, Caroline; Campbell, Archie; Harris, Sarah; Deary, Ian J; Starr, John; Gatcombe, Laura; Pinna, Maria; Briggs, Sarah; Martin, Lynn; Jaeger, Emma; Sharma-Oates, Archana; East, James; Leedham, Simon; Arnold, Roland; Johnstone, Elaine; Wang, Haitao; Kerr, David; Kerr, Rachel; Maughan, Tim; Kaplan, Richard; Al-Tassan, Nada; Palin, Kimmo; Hänninen, Ulrika A; Cajuso, Tatiana; Tanskanen, Tomas; Kondelin, Johanna; Kaasinen, Eevi; Sarin, Antti-Pekka; Eriksson, Johan G; Rissanen, Harri; Knekt, Paul; Pukkala, Eero; Jousilahti, Pekka.
Afiliación
  • Law PJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Timofeeva M; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Fernandez-Rozadilla C; Grupo de Medicina Xenómica, Fundación Pública Galega de Medicina Xenómica, Instituto de Investigación de Santiago, Santiago de Compostela, 15706, Spain.
  • Broderick P; Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK.
  • Studd J; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Fernandez-Tajes J; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Farrington S; Wellcome Centre for Human Genetics, McCarthy Group, Roosevelt Drive, Oxford, OX3 7BN, UK.
  • Svinti V; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Palles C; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Orlando G; Gastrointestinal Cancer Genetics Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK.
  • Sud A; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Holroyd A; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Penegar S; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Theodoratou E; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Vaughan-Shaw P; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Campbell H; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, UK.
  • Zgaga L; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Hayward C; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Campbell A; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, UK.
  • Harris S; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Deary IJ; Department of Public Health and Primary Care, Institute of Population Health, Trinity College Dublin, University of Dublin, Dublin, D02 PN40, Ireland.
  • Starr J; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Gatcombe L; Generation Scotland, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Pinna M; Generation Scotland, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Briggs S; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
  • Martin L; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
  • Jaeger E; Generation Scotland, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Sharma-Oates A; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
  • East J; Generation Scotland, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Leedham S; Medical Genetics Section, Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Arnold R; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
  • Johnstone E; Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK.
  • Wang H; Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK.
  • Kerr D; Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK.
  • Kerr R; Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK.
  • Maughan T; Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK.
  • Kaplan R; Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK.
  • Al-Tassan N; Translational Gastroenterology Unit, Nuffield Department. of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
  • Palin K; Wellcome Centre for Human Genetics, McCarthy Group, Roosevelt Drive, Oxford, OX3 7BN, UK.
  • Hänninen UA; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
  • Cajuso T; Cancer Bioinfomatics Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK.
  • Tanskanen T; Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7LE, UK.
  • Kondelin J; Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7LE, UK.
  • Kaasinen E; Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
  • Sarin AP; Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7LE, UK.
  • Eriksson JG; Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7LE, UK.
  • Rissanen H; Medical Research Council Clinical Trials Unit, Aviation House, 125 Kingsway, London, WC2B 6NH, UK.
  • Knekt P; Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, 11211, Saudi Arabia.
  • Pukkala E; Department of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.
  • Jousilahti P; Department of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.
Nat Commun ; 10(1): 2154, 2019 05 14.
Article en En | MEDLINE | ID: mdl-31089142
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Predisposición Genética a la Enfermedad / Sitios Genéticos Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Predisposición Genética a la Enfermedad / Sitios Genéticos Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido