Targeted Transgene Activation in the Brain Tissue by Systemic Delivery of Engineered AAV1 Expressing CRISPRa.

Lau, Cia-Hin; Ho, Jonathan Weng-Thim; Lo, Pik Kwan; Tin, Chung

Lau, Cia-Hin; Ho, Jonathan Weng-Thim; Lo, Pik Kwan; Tin, Chung.

Afiliación

Lau CH; Department of Biomedical Engineering, City University of Hong Kong, Kowloon Tong, Hong Kong.
Ho JW; Department of Biomedical Engineering, City University of Hong Kong, Kowloon Tong, Hong Kong.
Lo PK; Department of Chemistry, City University of Hong Kong, Kowloon Tong, Hong Kong; CityU Shenzhen Research Institute, Shenzhen, China.
Tin C; Department of Biomedical Engineering, City University of Hong Kong, Kowloon Tong, Hong Kong; CityU Shenzhen Research Institute, Shenzhen, China. Electronic address: chungtin@cityu.edu.hk.

Mol Ther Nucleic Acids ; 16: 637-649, 2019 Jun 07.

Article en En | MEDLINE | ID: mdl-31108320

Palabras clave

AAV capsid; CRISPR activation; CRISPR interference; adeno-associated virus; brain delivery; cis-regulatory elements

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mol Ther Nucleic Acids Año: 2019 Tipo del documento: Article País de afiliación: Hong Kong Pais de publicación: Estados Unidos

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