West Nile virus vaccines - current situation and future directions.
Hum Vaccin Immunother
; 15(10): 2337-2342, 2019.
Article
en En
| MEDLINE
| ID: mdl-31116691
ABSTRACT
West Nile virus (WNV) is a widely spread human pathogenic arthropod-borne virus. It can lead to severe, sometimes fatal, neurological disease. Over the last two decades, several vaccine candidates for the protection of humans from WNV have been developed. Some technologies were transferred into clinical testing, but these approaches have not yet led to a licensed product. This review summarizes the current status of a human WNV vaccine and discusses reasons for the lack of clinically advanced product candidates. It also discusses the problem of immunological cross-reactivity between flaviviruses and how it can be addressed during vaccine development.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fiebre del Nilo Occidental
/
Virus del Nilo Occidental
/
Vacunas contra el Virus del Nilo Occidental
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Hum Vaccin Immunother
Año:
2019
Tipo del documento:
Article
País de afiliación:
Alemania