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A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®.
Betts, Alison; Haddish-Berhane, Nahor; Shah, Dhaval K; van der Graaf, Piet H; Barletta, Frank; King, Lindsay; Clark, Tracey; Kamperschroer, Cris; Root, Adam; Hooper, Andrea; Chen, Xiaoying.
Afiliación
  • Betts A; Department of Biomedicine Design, Pfizer Inc., 610 Main Street, Cambridge, Massachusetts, 02139, USA. alison.betts@pfizer.com.
  • Haddish-Berhane N; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, 2300 RA, Leiden, The Netherlands. alison.betts@pfizer.com.
  • Shah DK; Janssen Research & Development, LLC, Spring House, Pennsylvania, 19477, USA.
  • van der Graaf PH; Department of Pharmaceutical Sciences, 455 Kapoor Hall, University at Buffalo, The State University of New York, Buffalo, New York, 14214-8033, USA.
  • Barletta F; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, 2300 RA, Leiden, The Netherlands.
  • King L; Oncology Research Unit, Pfizer Inc., 401 N Middletown Rd., Pearl River, New York, 10965, USA.
  • Clark T; Department of Biomedicine Design, Pfizer Inc., 1 Burtt Road, Andover, Massachusetts, USA.
  • Kamperschroer C; Established Med Business, Pfizer Inc., Eastern Point Rd, Groton, Connecticut, 06340, USA.
  • Root A; Department of Immunotoxicology, Pfizer Inc., 558 Eastern Point Road, Groton, Connecticut, 06340, USA.
  • Hooper A; Department of Biomedicine Design, Pfizer Inc., 610 Main Street, Cambridge, Massachusetts, 02139, USA.
  • Chen X; Oncology Research Unit, Pfizer Inc., 401 N Middletown Rd., Pearl River, New York, 10965, USA.
AAPS J ; 21(4): 66, 2019 05 22.
Article en En | MEDLINE | ID: mdl-31119428
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadherinas / Complejo CD3 / Anticuerpos Biespecíficos / Modelos Biológicos / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: AAPS J Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadherinas / Complejo CD3 / Anticuerpos Biespecíficos / Modelos Biológicos / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: AAPS J Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos