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Circulating miR-20a and miR-26a as Biomarkers in Prostate Cancer
Mohammadi Torbati, Peyman; Asadi, Fatemeh; Fard-Esfahani, Pezhman.
Afiliación
  • Mohammadi Torbati P; Department of Pathology, Labbafi-Nezhad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Asadi F; Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran. Email: fard-esfahani@pasteur.ac.ir
  • Fard-Esfahani P; Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran. Email: fard-esfahani@pasteur.ac.ir
Asian Pac J Cancer Prev ; 20(5): 1453-1456, 2019 May 25.
Article en En | MEDLINE | ID: mdl-31127907
Objective: Circulating microRNAs (miRNAs), present in body fluids, have been considering importance as cancer biomarkers. The primary aim of this study was to assess whether circulatory miR-20a and miR-26a can be used as diagnostic biomarkers in prostate cancer (PCa). Methods: Relative expression miR-20a and miR-26a has been assessed in 40 patients with PCa and 40 non-cancerous volunteer. Sample Collection of patients was performed before and one week after prostatectomy. Total RNA was extracted from serum and miR-20a and miR-26a expressions were quantified by using Real-Time PCR method. Results: miR-20a was significantly up-regulated in pre-operation serum samples of PCa patients compared to the serum samples of non-cancerous controls, however, in post-operation samples no significant differences was showed. miR-26a level was not significantly decreased in pre and post-operation serum samples compared to the serum samples of controls. However, the expression level ratios of both miR-20a and miR-26a were insignificantly decreased when post-operation serum samples compared to pre-operation ones. Conclusion: Decrement of circulating miR-20a and miR-26a in patients after surgery may reflect the tumoral origin of those microRNAs and the results may use for tumor remnant monitoring after prostatectomy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Biomarcadores de Tumor / MicroARNs / MicroARN Circulante Límite: Humans / Male Idioma: En Revista: Asian Pac J Cancer Prev Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Tailandia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Biomarcadores de Tumor / MicroARNs / MicroARN Circulante Límite: Humans / Male Idioma: En Revista: Asian Pac J Cancer Prev Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Tailandia