Pd-catalysed selective C(sp3)-H arylation and acetoxylation of alcohols.

ABSTRACT

A palladium catalyzed selective C(sp3)-H arylation and acetoxylation of alcohols using a practical bidentate auxiliary were developed. Masked alcohols were selectively arylated at the ß-position with diverse aryl iodides for the first time. Moreover, an efficient and site-selective acetoxylation of various primary methyl, methylene, and benzylic C(sp3)-H bonds was performed by using cheap K2S2O8 as the external oxidant.