Design, Synthesis and Evaluation of 8-Thiosubstituted 1,3,7- Trimethylxanthine Hydrazones with In-vitro Neuroprotective and MAO-B Inhibitory Activities.

Mitkov, Javor; Kasabova-Angelova, Alexandra; Kondeva-Burdina, Magdalena; Tzankova, Virginia; Tzankova, Diana; Georgieva, Maya; Zlatkov, Alexander

Mitkov, Javor; Kasabova-Angelova, Alexandra; Kondeva-Burdina, Magdalena; Tzankova, Virginia; Tzankova, Diana; Georgieva, Maya; Zlatkov, Alexander.

Afiliación

Mitkov J; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, 1000, Sofia, Bulgaria.
Kasabova-Angelova A; Laboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, 1000, Sofia, Bulgaria.
Kondeva-Burdina M; Laboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, 1000, Sofia, Bulgaria.
Tzankova V; Laboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, 1000, Sofia, Bulgaria.
Tzankova D; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, 1000, Sofia, Bulgaria.
Georgieva M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, 1000, Sofia, Bulgaria.
Zlatkov A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, 1000, Sofia, Bulgaria.

Med Chem ; 16(3): 326-339, 2020.

Article en En | MEDLINE | ID: mdl-31146671

Asunto(s)

Antiparkinsonianos/farmacología; Hidrazonas/farmacología; Inhibidores de la Monoaminooxidasa/farmacología; Fármacos Neuroprotectores/farmacología; Xantinas/farmacología; Animales; Antiparkinsonianos/síntesis química; Diseño de Fármacos; Humanos; Hidrazonas/síntesis química; Inhibidores de la Monoaminooxidasa/síntesis química; Neuroprotección/efectos de los fármacos; Fármacos Neuroprotectores/síntesis química; Ratas; Sinaptosomas/efectos de los fármacos; Xantinas/síntesis química

Palabras clave

Alzheimer's disease; Parkinson's disease; SH-SY5Y; aromatic hydrazide-hydrazones; monoamine oxidase B; xanthine.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Xantinas / Fármacos Neuroprotectores / Hidrazonas / Inhibidores de la Monoaminooxidasa / Antiparkinsonianos Límite: Animals / Humans Idioma: En Revista: Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Bulgaria Pais de publicación: Países Bajos

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