Structural basis for &#945;-bungarotoxin insensitivity of neuronal nicotinic acetylcholine receptors.

Sine, Steven M; Strikwerda, John R; Mazzaferro, Simone

Structural basis for α-bungarotoxin insensitivity of neuronal nicotinic acetylcholine receptors.

Sine, Steven M; Strikwerda, John R; Mazzaferro, Simone.

Afiliación

Sine SM; Receptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA; Department of Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA; Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA. Electronic address: sine.steven@mayo.edu.
Strikwerda JR; Receptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA.
Mazzaferro S; Receptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA.

Neuropharmacology ; 160: 107660, 2019 12 01.

Article en En | MEDLINE | ID: mdl-31163179

Asunto(s)

Bungarotoxinas/metabolismo; Neuronas/metabolismo; Receptores Nicotínicos/química; Receptores Nicotínicos/metabolismo; Sitios de Unión; Bungarotoxinas/química; Células HEK293; Humanos; Ligandos; Conformación Molecular; Mutación; Receptores Nicotínicos/genética

Palabras clave

3D structure; Inter-residue interactions; Neuronal nicotinic acetylcholine receptor; Radio-ligand binding; Single channel recording; Sucrose gradient analysis; α-Bungarotoxin; α-subunit

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bungarotoxinas / Receptores Nicotínicos / Neuronas Límite: Humans Idioma: En Revista: Neuropharmacology Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido

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