The Smad3-miR-29b/miR-29c axis mediates the protective effect of macrophage migration inhibitory factor against cardiac fibrosis.

Liang, Jing-Nan; Zou, Xiao; Fang, Xian-Hong; Xu, Jin-Dong; Xiao, Zhen; Zhu, Jie-Ning; Li, Hui; Yang, Jing; Zeng, Ni; Yuan, Shu-Jing; Pan, Rong; Fu, Yong-Heng; Zhang, Ming; Luo, Jian-Fang; Wang, Sheng; Shan, Zhi-Xin

Liang, Jing-Nan; Zou, Xiao; Fang, Xian-Hong; Xu, Jin-Dong; Xiao, Zhen; Zhu, Jie-Ning; Li, Hui; Yang, Jing; Zeng, Ni; Yuan, Shu-Jing; Pan, Rong; Fu, Yong-Heng; Zhang, Ming; Luo, Jian-Fang; Wang, Sheng; Shan, Zhi-Xin.

Afiliación

Liang JN; Guangdong Provincial Key Laboratory of Clinical Pharmacology, Guangdong Cardiovascular Institute, Guangzhou 510080, China; Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China; School of Pharmacology, Southern Med
Zou X; Guangdong Provincial Key Laboratory of Clinical Pharmacology, Guangdong Cardiovascular Institute, Guangzhou 510080, China; Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Fang XH; Guangdong Provincial Key Laboratory of Clinical Pharmacology, Guangdong Cardiovascular Institute, Guangzhou 510080, China.
Xu JD; Department of Anesthesiology, Guangdong Cardiovascular Institute, Guangzhou 510080, China.
Xiao Z; Guangdong Provincial Key Laboratory of Clinical Pharmacology, Guangdong Cardiovascular Institute, Guangzhou 510080, China; Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Zhu JN; Guangdong Provincial Key Laboratory of Clinical Pharmacology, Guangdong Cardiovascular Institute, Guangzhou 510080, China; Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Li H; School of Pharmacology, Southern Medical University, Guangzhou 510515, China.
Yang J; School of Medicine, South China University of Technology, Guangzhou 510632, China.
Zeng N; School of Medicine, South China University of Technology, Guangzhou 510632, China.
Yuan SJ; School of Medicine, South China University of Technology, Guangzhou 510632, China.
Pan R; School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510632, China.
Fu YH; Guangdong Provincial Key Laboratory of Clinical Pharmacology, Guangdong Cardiovascular Institute, Guangzhou 510080, China; Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Zhang M; Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Luo JF; Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Wang S; Department of Anesthesiology, Guangdong Cardiovascular Institute, Guangzhou 510080, China.
Shan ZX; Guangdong Provincial Key Laboratory of Clinical Pharmacology, Guangdong Cardiovascular Institute, Guangzhou 510080, China; Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China. Electronic address: shanzhixin@gdph.

Biochim Biophys Acta Mol Basis Dis ; 1865(9): 2441-2450, 2019 09 01.

Article en En | MEDLINE | ID: mdl-31175931

Asunto(s)

Factores Inhibidores de la Migración de Macrófagos/metabolismo; MicroARNs/metabolismo; Proteína smad3/metabolismo; Regiones no Traducidas 3'; Animales; Antígenos de Diferenciación de Linfocitos B/química; Antígenos de Diferenciación de Linfocitos B/genética; Antígenos de Diferenciación de Linfocitos B/metabolismo; Cardiomegalia/patología; Cardiomegalia/veterinaria; Colágeno Tipo I/metabolismo; Cadena alfa 1 del Colágeno Tipo I; Fibroblastos/citología; Fibroblastos/metabolismo; Fibrosis; Antígenos de Histocompatibilidad Clase II/química; Antígenos de Histocompatibilidad Clase II/genética; Antígenos de Histocompatibilidad Clase II/metabolismo; Factores Inhibidores de la Migración de Macrófagos/antagonistas & inhibidores; Factores Inhibidores de la Migración de Macrófagos/genética; Masculino; Metaloproteinasa 2 de la Matriz/química; Metaloproteinasa 2 de la Matriz/genética; Metaloproteinasa 2 de la Matriz/metabolismo; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; MicroARNs/química; MicroARNs/genética; Miocardio/citología; Miocardio/metabolismo; Interferencia de ARN; ARN Interferente Pequeño/metabolismo; Factor de Crecimiento Transformador beta2/química; Factor de Crecimiento Transformador beta2/genética; Factor de Crecimiento Transformador beta2/metabolismo; Regulación hacia Arriba

Palabras clave

Cardiac fibrosis; Macrophage migration inhibitory factor; MicroRNA-29b-3p; MicroRNA-29c-3p; Smad3

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores Inhibidores de la Migración de Macrófagos / MicroARNs / Proteína smad3 Idioma: En Revista: Biochim Biophys Acta Mol Basis Dis Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos

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